Modification of the Abbott Cyclosporine Monoclonal Whole Blood Assay
نویسندگان
چکیده
منابع مشابه
Specimen dilution for C2 monitoring with the Abbott TDxFLx cyclosporine monoclonal whole blood assay.
studies. The II for men and women separately were not different from the II of the reference population. This provides objective evidence that stratified reference intervals according to gender are unnecessary. At 95% confidence , the reference change value of plasma total iPF 2␣-III was 72.9%, suggesting that relatively large differences between the results of sequential specimens would be req...
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The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Cyclosporine (CsA) immunoassay in 7 clinical laboratories in comparison to liquid chromatography/tandem mass spectrometry (LC/MS/MS), Abbott TDx, Cobas Integra 800, and the Dade Dimension Xpand immunoassay. The ARCHITECT assay uses a whole blood specimen, a pretreatment step with organic reagents to p...
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We describe a chemiluminescent immunoassay (CLI) for measuring cyclosporine in whole blood. Its sensitivity and accuracy are comparable with those of an RIA method that makes use of the same specific monoclonal antibody. The comparison with the RIA method was excellent: y(RIA) = x(CLI) + 11.24 (r = 0.99). In our procedure the samples are incubated with cyclosporin C-hemisuccinate-aminobutyl-N-e...
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ment. We saw no systematic error associated with a plot of the residuals (data not shown). The linear model accounted for the data, and the underlying assumptions (linearity, stable variance) of the model have not been violated. The upper limit of linearity was 3.377 mmol/L (700 mg/L), although we routinely used a linear calibration up to 1.930 mmol/L (400 mg/L), which encompassed almost all of...
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Two hereditary platelet disorders, Bernard-Soulier syndrome and Glanzmann's thrombasthenia, are characterized by selective deficiencies of platelet membrane glycoproteins. Murine monoclonal antibodies were developed against platelet membrane glycoprotein Ib and against the glycoprotein IIb/IIIa complex. A rapid whole blood assay for the deficiency of these glycoproteins was developed and used t...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1998
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/44.7.1581